What Is ‘Ozempic Face’? Understanding Facial Volume Loss After Weight Loss Injections

Weight loss medications like Ozempic, Mounjaro, and other GLP-1 agonists have become increasingly popular in recent years for helping people achieve significant weight loss and improve their overall health. While these treatments offer undeniable benefits, a lesser-known but increasingly talked about side effect is something known as ‘Ozempic face’.

At TM Aesthetics, we often see patients concerned about facial changes following rapid or substantial weight loss, so in this blog, we’ll explain what Ozempic face is, why it happens, and the safe, effective treatment options available to restore natural facial balance.

What Is ‘Ozempic Face’?

‘Ozempic face’ is a term used to describe the facial volume loss and skin laxity that can develop after significant weight loss, particularly when it happens quickly. As the body sheds fat, the fat pads in the face also reduce in size — especially in areas like the cheeks, temples, under-eye region, and jawline. This can result in:

  • Hollow, gaunt cheeks
  • Deepened smile lines and nasolabial folds
  • Under-eye hollowness
  • Loose, sagging skin around the jawline
  • An overall tired or aged appearance

While the phrase references Ozempic, it can occur after using any GLP-1 medication, such as Mounjaro (tirzepatide) or Saxenda (liraglutide), or after rapid weight loss through other means.

Why Does It Happen?

The face relies on fat pads and underlying soft tissue to provide youthful contours and natural lift. When weight loss is significant, these supportive fat pads diminish, leaving the skin without its usual foundation. As a result:

  • Facial volume reduces
  • Skin becomes lax due to reduced internal support
  • Fine lines and folds become more pronounced

This is a natural part of rapid weight loss and not unique to injectable weight loss medications — but the pace of change with GLP-1 medications can make it more noticeable.

How Do We Treat ‘Ozempic Face’ at TM Aesthetics?

A common misconception is that skin tightening or hydrating treatments alone will address these concerns. However, it’s essential to understand:

Without adequate internal support, skin boosters and tightening treatments won’t be fully effective. Restoring facial volume is the first priority.

At TM Aesthetics, we take a structured, personalised approach to treat Ozempic face, focusing on both volume replacement and collagen stimulation to restore balance and freshness to the face.

Recommended Treatments

1. Dermal Fillers

Using premium, hyaluronic acid-based dermal fillers, we carefully restore lost volume in the mid-face, cheeks, jawline, and temples. This helps to lift and reshape facial contours while keeping your results looking natural and harmonious.

2. Collagen-Stimulating Treatments

  • Radiesse: A calcium-based collagen stimulator, Radiesse not only restores facial volume but also encourages the body’s natural collagen production over time. It’s particularly effective for areas like the cheeks and lower face.
  • Lenisna: A (PDLLA) collagen booster that enhances skin thickness, elasticity, and firmness. While it doesn’t replace lost volume like a filler, it’s an excellent option for rebuilding skin quality after the initial volume has been restored.

3. Skin Boosters and Polynucleotide Treatments

Once facial structure is corrected, skin quality can be further improved with advanced skin boosters and polynucleotide injectables. These treatments deeply hydrate, improve skin texture, and enhance elasticity — but work best when underlying support is already addressed.

4. Exosome and PRP Therapy

For overall skin regeneration, exosomes and platelet-rich plasma (PRP) treatments can stimulate natural collagen production, improve dermal health, and enhance skin glow and resilience.

5. Microneedling 

As a final touch, microneedling can gently firm mildly lax skin and refine skin texture for a smoother, more rejuvenated appearance.

Final Thoughts

While Ozempic face is a natural consequence of rapid weight loss, it’s entirely manageable with the right combination of advanced aesthetic treatments. At TM Aesthetics, our priority is to help you maintain the health benefits of your weight loss journey while restoring a fresh, confident, and natural-looking appearance.

If you’ve experienced changes to your facial volume or skin quality after using weight loss injections, we’re here to help. Book your consultation for a full face assessment.

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